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環(huán)境友好型烴基膦酸酯類除草劑

環(huán)境友好型烴基膦酸酯類除草劑

定 價(jià):¥280.00

作 者: 賀紅武,彭浩,譚效松 著
出版社: 化學(xué)工業(yè)出版社
叢編項(xiàng):
標(biāo) 簽: 農(nóng)業(yè)/林業(yè) 植物保護(hù)

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ISBN: 9787122213815 出版時(shí)間: 2015-03-01 包裝: 精裝
開(kāi)本: 16開(kāi) 頁(yè)數(shù): 455 字?jǐn)?shù):  

內(nèi)容簡(jiǎn)介

《環(huán)境友好型烴基膦酸酯類除草劑》系統(tǒng)總結(jié)了我國(guó)新農(nóng)藥創(chuàng)制性的成果——烷基膦酸酯類除草劑的研發(fā)總結(jié)。從化合物的合成、毒性研究、作用機(jī)制,從中試到生產(chǎn)整個(gè)程序,為今后我國(guó)農(nóng)藥新創(chuàng)制提供一條有效途徑。
  《環(huán)境友好型烴基膦酸酯類除草劑》可供廣大新農(nóng)藥研發(fā)、生產(chǎn)等人員閱讀,也可供高等學(xué)校農(nóng)藥、植保等相關(guān)專業(yè)師生閱讀。

作者簡(jiǎn)介

賀紅武,華中師范大學(xué),教授、所長(zhǎng),畢業(yè)于華中師范大學(xué)化學(xué)專業(yè)。在日本九州大學(xué)獲農(nóng)學(xué)博士學(xué)位。1989~1990年日本九州大學(xué)農(nóng)學(xué)部農(nóng)藥化學(xué)研究室訪問(wèn)研究員,1996年晉升教授,1998~1999年德國(guó)美因茲大學(xué)藥物化學(xué)研究所訪問(wèn)教授,1999年獲博士生導(dǎo)師資格,2001年赴日本九州大學(xué)農(nóng)學(xué)研究院農(nóng)藥化學(xué)研究室和日本神戶大學(xué)農(nóng)學(xué)部生物功能研究室進(jìn)行為期3個(gè)月的學(xué)術(shù)訪問(wèn)。2007,8月-11月:日本九州大學(xué)農(nóng)學(xué)研究院農(nóng)藥化學(xué)研究室,訪問(wèn)教授。
  兼任社會(huì)職務(wù):第六屆國(guó)務(wù)院學(xué)位委員會(huì)植物保護(hù)學(xué)科評(píng)議組成員,中國(guó)化工學(xué)會(huì)農(nóng)藥專業(yè)委員會(huì)委員 ; 中國(guó)植物保護(hù)學(xué)會(huì)農(nóng)藥學(xué)分會(huì)委員;湖北省化學(xué)化工學(xué)會(huì)理事;湖北省化學(xué)化工學(xué)會(huì)農(nóng)藥專業(yè)委員會(huì)主任委員《世界農(nóng)藥》、《農(nóng)藥》、《現(xiàn)代農(nóng)藥》、《農(nóng)藥學(xué)學(xué)報(bào)》、《化學(xué)與生物工程》、《農(nóng)藥研究與應(yīng)用》雜志編委。
  長(zhǎng)期從事有機(jī)化學(xué)、農(nóng)藥化學(xué)、有機(jī)磷化學(xué)以及新農(nóng)藥創(chuàng)制研究工作。先后承擔(dān)國(guó)家及省部級(jí)的科研項(xiàng)目40余項(xiàng),連續(xù)承擔(dān)國(guó)家七.五,八.五,九.五十.五、十一.五國(guó)家新農(nóng)藥創(chuàng)制科技攻關(guān)項(xiàng)目。先后承擔(dān)了六個(gè)農(nóng)藥新品種及一個(gè)農(nóng)藥增效劑的應(yīng)用基礎(chǔ)研究與工業(yè)化開(kāi)發(fā),其技術(shù)和成果在農(nóng)藥工業(yè)中得到創(chuàng)新性的應(yīng)用和發(fā)展。為具有我國(guó)發(fā)明專利權(quán)的新型除草劑氯酰草膦(己獲農(nóng)藥三證。)的第一發(fā)明人。
  在新農(nóng)藥品種的創(chuàng)制研究、技術(shù)開(kāi)發(fā)、產(chǎn)業(yè)化等工作中獲得11項(xiàng)授權(quán)中國(guó)發(fā)明專利, 獲得湖北省自然科學(xué)獎(jiǎng)一等獎(jiǎng), 教育部科技進(jìn)步一等獎(jiǎng),教育部科技進(jìn)步二等獎(jiǎng);湖北省科技進(jìn)步二等獎(jiǎng)二項(xiàng);八.五”國(guó)家技術(shù)創(chuàng)新優(yōu)秀項(xiàng)目獎(jiǎng)等9項(xiàng)省部級(jí)科技獎(jiǎng)勵(lì)。2001年評(píng)為湖北省科技精英和全國(guó)優(yōu)秀科技工作者。2009獲得建國(guó)60周年中國(guó)農(nóng)藥工業(yè)突出貢獻(xiàn)獎(jiǎng)。

圖書(shū)目錄

1 Overview
1.1 Introduction
1.1.1 Mode of Action of Herbicide
1.1.2 Herbicide Resistance
1.1.3 New Opportunity for Novel Herbicides
1.1.4 Basic Methodology for Discovery of Hit/Lead Compounds
1.2 Pyruvate Dehydrogenase Complex (PDHc)
1.2.1 Function of PDHc
1.2.2 Distribution of PDHc
1.2.3 Plant PDHc E1.as Site of Action of Herbicide
1.3 Progress in the Research of PDHc Inhibitors
1.3.1 OP Compounds as Inhibitors of E coli PDHc
1.3.2 OP Compounds as Inhibitors of Plant PDHc
1.3.3 Enzyme-Selective Inhibition of OP Compounds
1.4 Design of Novel PDHc E1 Inhibitors as Herbicides
1.4.1 Selecting Plant PDHc E1.as Target of New Herbicide
1.4.2 PDHc E1 Inhibitor Acylphosphonate as Hit Compound
1.4.3 Finding Lead Structure IA
1.4.4 Optimization Strategy
1.5 Book Chapter Organization
References

2 Alkylphosphonates
2.1.(Alkyl or Substituted Phenyl)Methylphosphonates IA-IF
2.1.1 Introduction
2.1.2 Synthesis of O,O-Dialkyl
1-Hydroxyalkylphosphonates M2
2.1.3 Synthesis of Substituted Phenoxyacetic Acids M and Substituted Phenoxyacetyl Chlorides M5
2.1.4 Synthesis of IA-IF
2.1.5 Spectroscopic Analysis of IA-IF
2.1.6 Crystal Structure Analysis of IC-7
2.1.7 Herbicidal Activity of IA-IF
2.1.8 Structure-Herbicidal Activity Relationships
2.1.9 Herbicidal Activity of IC-22
2.1.10 Summary
2.2 Heterocyclylmethylphosphonates IG-IJ
2.2.1 Introduction
2.2.2 Synthesis of IG-IJ
2.2.3 Spectroscopic Analysis of IG-IJ
2.2.4 Crystal Structure Analysis of IH-18.and IG-21
2.2.5 Herbicidal Activity of IG-IJ
2.2.6 Structure-Herbicidal Activity Relationships
2.2.7 Herbicidal Activity of IG-21
2.2.8 Summary
2.3.(1-Phenyl-1,2,4-Triazol-3-yloxyacetoxy) Alkylphosphonates IK
2.3.1 Introduction
2.3.2 Synthesis of IK
2.3.3 Spectroscopic Analysis of IK
2.3.4 Herbicidal Activity of IK
2.3.5 Summary
References

3 Salts of Alkylphosphonates
3.1 Alkali Metal Salts of O-Alkyl Alkylphosphonic Acids IIA-IIE
3.1.1 Introduction
3.1.2 Synthesis of IIA-IIE
3.1.3 Spectroscopic Analysis of IIA-IIE
3.1.4 Crystal Structure Analysis of IIB-20
3.1.5 Herbicidal Activity of IIA-IIE
3.1.6 Summary
3.2 Alkali Metal Salts of Alkylphosphonic Acids IIF, IIGandIIH
3.2.1 Introduction
3.2.2 Synthesis of IIF, IIG and IIH
3.2.3 Spectroscopic Analysis of IIF, IIG and IIH
3.2.4 Herbicidal Activity of IIF, IIG and IIH
3.2.5 Summary
3.3.t-Butylaminium Salts of Alkylphosphonates IIJ
3.3.1 Introduction
3.3.2 Synthesis of IIJ
3.3.3 Spectroscopic Analysis of IIJ
3.3.4 Crystal Structure Analysis of IIJ-
3.3.5 Herbicidal Activity of IIJ
3.3.6 Summary
References

4 Alkylphosphinates
4.1 Alkylphosphinates IIIA-IIIG
4.1.1 Introduction
4.1.2 Synthesis of Dichloro(Methyl)Phosphine M10
4.1.3 Synthesis of O-Methyl (1-Hydroxyalkyl)-Methylphosphinates M12
4.1.4 Synthesis of IIIA-IIIG
4.1.5 Spectroscopic Analysis of IIIA-IIIG
4.1.6 Crystal Structure Analysis of IIIE-
4.1.7 Herbicidal Activity of IIIA-IIIG
4.1.8 Summary
4.2 Sodium Salts of Alkylphosphinic Acids IIIH
4.2.1 Introduction
4.2.2 Synthesis of IIIH
4.2.3 Spectroscopic Analysis of IIIH
4.2.4 Herbicidal Activity of IIIH
4.2.5 Summary
4.3.[(5-Methylisoxazol-3-yloxyacetoxy)Alkyl]-Methylphosphinates IIIJ
4.3.1 Introduction
4.3.2 Synthesis of IIIJ
4.3.3 Spectroscopic Analysis of IIIJ
4.3.4 Herbicidal Activity of IIIJ
4.3.5 Summary
References

5 Cyclic Phosphonates and Caged Bicyclic Phosphates
5.1 Cyclic 1-Hydroxyalkylphosphonates IVA and IVB
5.1.1 Introduction
5.1.2 Synthesis of IVA and IVB
5.1.3 Spectroscopic Analysis of IVA and IVB
5.1.4 Crystal Structure Analysis of IVA-3
5.1.5 Herbicidal Activity of IVA and IVB
5.1.6 Summary
5.2 Cyclic Alkylphosphonates IVC-IVF
5.2.1 Introduction
5.2.2 Synthesis of IVC-IVF
5.2.3 Spectroscopic Analysis of IVC-IVF
5.2.4 Crystal Structure Analysis of IVC-
5.2.5 Herbicidal Activity of IVC-IVF
5.2.6 Summary
5.3 Caged Bicyclic Phosphates IVG and IVH
5.3.1 Introduction
5.3.2 Synthesis of IVG and IVH
5.3.3 Spectroscopic Analysis of IVG and IVH
5.3.4 Crystal Structure Analysis of IVG-
5.3.5 Herbicidal Activity of IVG and IVH
5.3.6 Summary
References

6 Optically Active Alkylphosphonates
6.1 Optically Active 1-Hydroxyalkylphosphonates IVB and M2
6.1.1 Introduction
6.1.2 Asymmetric Synthesis of 1-Hydroxyalkylphosphonates
IVB and M2.via Hydrophosphonylation
6.1.3 Asymmetric Synthesis of 1-Hydroxyalkylphosphonates M2.via Hydroxylation
6.1.4 Summary
6.2 Optically Active (Substituted Phenyl)methylphosphonates IA,IEandIF
6.2.1 Introduction
6.2.2 Synthesis of Optically Active IA, IE and IF
6.2.3 Herbicidal Activity of Optically Active IA, IEandIF
6.2.4 Summary
6.3 Optically Active Substituted Ethylphosphonates IA and IC
6.3.1 Introduction
6.3.2 Synthesis of Optically Active IA and IC
6.3.3 Herbicidal Activity of Optically Active IA and IC
6.3.4 Aquatic Toxicity of Optically Active IA and IC
6.3.5 Summary
References

7 Biochemical Mechanism of Alkylphosphonates
7.1 Molecular Docking and 3D-QSAR Studies
7.1.1 Introduction
7.1.2 Binding Conformational Analysis
7.1.3 CoMFA and CoMSIA Analysis
7.1.4 Validation of the 3D-QSAR Models
7.1.5 Molecular Docking
7.1.6 Molecular Alignment and 3D-QSAR Modeling
7.1.7 CoMFA Analysis and CoMSIA Analysis Modeling
7.1.8 PLS Calculations and Validations
7.1.9 Summary
7.2 Enzyme Inhibition
7.2.1 Introduction
7.2.2 Inhibitory Potency Against Plant PDHc
7.2.3 Kinetic Experiment of PDHc
7.2.4 Selective Enzyme Inhibition
7.2.5 Structure-Activity Relationships
7.2.6 Assay of PDHc from Plant
7.2.7 Assay of PDHc from E coli and Pig Heart
7.2.8 Assay of Other Enzymes
7.2.9 Summary
References

8 Evaluation and Application of Clacyfos and HWS
8.1 Evaluation of Clacyfos
8.1.1 Introduction
8.1.2 Physiochemical Properties
8.1.3 Stability of Clacyfos
8.1.4 Herbicidal Activity in Greenhouse
8.1.5 Systemic Property of Clacyfos
8.1.6 Rainfast Characteristics of Clacyfos
8.1.7 Field Trials of Clacyfos
8.1.8 Toxicity Evaluation
8.1.9 Environmental Fate
8.1.10 Residues
8.1.11 Adsorption of Clacyfos on Soils
8.1.12 Ecological Effects
8.1.13 Summary
8.2 Evaluation of HWS
8.2.1 Introduction
8.2.2 Physiochemical Properties
8.2.3 Herbicidal Activity in Greenhouse
8.2.4 Systemic Property of HWS
8.2.5 Rainfast Characteristics of HWS
8.2.6 Field Trials of HWS
8.2.7 Toxicity Evaluation
8.2.8 Ecological Effects
8.2.9 Summary
References

9 General Methodology
9.1 General Synthetic Procedure
9.1.1 Chemicals, Reagents, and Solvents
9.1.2 O,O-Dialkyl Phosphonates M1
9.1.3 O,O-Dialkyl 1-Hydroxyalkylphosphonates M2
9.1.4 O,O-Dialkyl 1-(Chloroacetoxy)-
Alkylphosphonates M3
9.1.5 Substituted Phenoxyacetic Acids M4
9.1.6 Substituted Phenoxyacetyl Chlorides M5
9.1.7 O,O-Dialkyl 1-(Substituted Phenoxyacetoxy)-Alkylphosphonates IA-IJ
9.1.8 Phenylhydrazinecarboxamide M6.and Sodium Triazol-3-olate M7
9.1.9.(1-Phenyl-1,2,4-Triazol-3-yloxyacetoxy)-Alkylphosphonates IK
9.1.10 Alkali Metal Salts of O-Alkyl Alkylphosphonic Acids IIA-IIE
9.1.11 O,O-Bis(Trimethylsilyl) Alkylphosphonates M8.and Alkylphosphonic Acids M9
9.1.12 Alkali Metal Salts of Alkylphosphonic Acids IIF-IIH
9.1.13.t-Butylaminium Salts of Alkylphosphonates IIJ
9.1.14 Dichloro(Methyl)Phosphine M10
9.1.15 O-Methyl Methylphosphinate M11
9.1.16 O-Methyl (1-Hydroxyalkyl)Methylphosphinates M12
9.1.17 Alkylphosphinates IIIA-IIIG
9.1.18 Sodium Salts of Alkylphosphinic Acids IIIH
9.1.19.3-Hydroxy-5-Methylisoxazole Derivatives M13-M16
9.1.20 O-Methyl [1-(5-Methylisoxazol-3-yloxyacetoxy)-Alkyl]Methylphosphinates IIIJ
9.1.21.1-Phenyl-2,2-Dimethyl-1,3-Propanediol M17
9.1.22 Cyclic Phosphonates M18
9.1.23 Cyclic 1-Hydroxyalkylphosphonates IVA and IVB
9.1.24 Substituted Phenoxypropionic Acids M19
9.1.25 Substituted Phenoxypropionyl Chlorides M20
9.1.26 Cyclic Alkylphosphonates IVC-IVF
9.1.27.4-(Hydroxymethyl)-2,6,7-Trioxa-1-Phosphabicyclo-[2.2.2]Octane-1-One/Thione M21/M22
9.1.28 Caged Bicyclic Phosphates IVG and IVH
9.1.29 Optically Active Cyclic 1-Hydroxyalkylphosphonates IVB
9.1.30 O,O-Diethyl (Substituted Benzyl)Phosphonates M23
9.1.31 Optically Active 1-Hydroxyalkylphosphonates M2
9.1.32 Optically Active (Substituted Phenyl)-Methylphosphonates IA, IE, and IF
9.1.33.1-Keto Phosphonates M24.and VinylphosphonatesM25
9.1.34 Optically Active 1-Substituted Ethylphosphonates IAandIC
9.2 General Information of Structural Characterization
9.3 Herbicidal Activity Assay
9.3.1 Test in Petri Dishes
9.3.2 Test in Greenhouse
References
Index

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