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藥用高分子材料

藥用高分子材料

定 價(jià):¥49.00

作 者: 劉黎,郭圣榮 編
出版社: 化學(xué)工業(yè)出版社
叢編項(xiàng):
標(biāo) 簽: 工業(yè)技術(shù) 化學(xué)工業(yè) 制藥化學(xué)工業(yè)

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ISBN: 9787122218131 出版時(shí)間: 2015-01-01 包裝: 平裝
開(kāi)本: 16開(kāi) 頁(yè)數(shù): 166 字?jǐn)?shù):  

內(nèi)容簡(jiǎn)介

  本教材是編者總結(jié)近十年的教學(xué)經(jīng)驗(yàn),從大量英文原版文獻(xiàn)和書(shū)籍中選取適合教學(xué)大綱要求的內(nèi)容編寫(xiě)而成,并對(duì)關(guān)鍵知識(shí)點(diǎn)配以中文導(dǎo)讀,便于學(xué)生閱讀和理解。全書(shū)共分6章,主要內(nèi)容如下:第一章為藥用輔料概述;第二章為高分子材料簡(jiǎn)介;第三章、第四章分別介紹選材于《Handbook of Pharmaceutical Excipients》(Fourth Edition,edited by Raymond C Rowe,Paul J Sheskey and Paul J Weller)中的天然高分子輔料和合成高分子輔料;第五章介紹現(xiàn)代藥物輸送系統(tǒng)研發(fā)中涉及的生物可降解高分子材料;第六章介紹幾類新型的高分子藥物輸送體系,包括:自組裝高分子和納米制劑、藥用水凝膠、高分子-藥物軛合物、高分子基因載體。

作者簡(jiǎn)介

  郭圣榮,上海交通大學(xué)藥學(xué)院,教授,浙江大學(xué)高分子化學(xué)與物理專業(yè)博士,曾赴美國(guó)佐治亞理工大學(xué)從事博士后研究。現(xiàn)任上海交通大學(xué)藥學(xué)院藥物控制釋放技術(shù)與醫(yī)用高分子課題組負(fù)責(zé)人,博士生導(dǎo)師。兼職上海市醫(yī)藥衛(wèi)生青年聯(lián)合會(huì)委員,世界中醫(yī)藥學(xué)會(huì)聯(lián)合會(huì)第一屆中藥新型給藥系統(tǒng)專業(yè)委員會(huì)常務(wù)理事。研究方向?yàn)椋?.新型藥物輸送系統(tǒng)制備和體內(nèi)外表征,如微、納米尺度藥劑,原位凝膠劑,植入劑等;2.新型藥用高分子材料的設(shè)計(jì)、制備、性狀和自組裝行為,如生物降解性、兩親性、離子性高分子材料;3.醫(yī)療器械與藥劑結(jié)合,如載藥消化道支架等。近5年來(lái)已完成和正在承擔(dān)的國(guó)家和省市級(jí)研究項(xiàng)目20項(xiàng),發(fā)表研究性論文100余篇,其中SCIE收錄論文60多篇。主編專著二本,主譯專著一本,參加編寫(xiě)和編譯專著多本。申請(qǐng)中國(guó)發(fā)明專利18項(xiàng),授權(quán)8項(xiàng)。先后獲明治乳業(yè)生命科學(xué)最高獎(jiǎng)(杰出獎(jiǎng))、國(guó)家科技進(jìn)步二等獎(jiǎng)、上海市自然科學(xué)三等獎(jiǎng)和中國(guó)藥學(xué)會(huì)科技三等獎(jiǎng)。

圖書(shū)目錄

Chapter 1. Introduction to Pharmaceutical Excipients
藥用輔料概述 1
1.1 Definition of pharmaceutical excipients 1
1.2 What are excipients doing in medicines? 2
1.3 Quality and safty of excipients 3
1.4 Relationship between polymers and pharmaceutical excipients 5
1.5 Specific notes for polymers used in drug delivery system 6
本章中文導(dǎo)讀 7
References 9
Chapter 2. Introduction to Polymers
高分子材料概述 10
2.1 What are polymers? 10
2.2 Polymer structure and morphology 11
2.2.1 Molecular weight 11
2.2.2 Configuration and conformation 12
2.2.3 Chain structure 14
2.2.4 Crystalline 15
2.3 Synthesis 17
2.3.1 Addition polymerization 17
2.3.2 Condensation polymerization 19
2.3.3 Cross-linking reaction 19
2.4 Characteristic properties of polymers 20
2.4.1 Thermal properties 20
2.4.2 Mechanical properties 22
2.4.3 Viscoelastic properties 23
2.5 Characterization techniques 23
2.5.1 Determination of molecular weight 23
2.5.2 Determination of structure 24
2.5.3 Differential scanning calorimetry 25
2.6 Fabrication and processing 26
2.6.1 Injection molding 27
2.6.2 Extrusion 27
2.6.3 Spinning 27
本章中文導(dǎo)讀 28
References 32
Chapter 3. Natural Polymers as Pharmaceutical Excipients
天然來(lái)源的藥用高分子輔料 33
3.1 Starch and its derivates 33
3.1.1 Starch 33
3.1.2 Pregelatinized starch 36
3.1.3 Dextrin 37
3.1.4 Cyclodextrin 39
3.1.5 Sodium carboxymethyl starch 42
本節(jié)中文導(dǎo)讀 44
3.2 Cellulose and its derivates 46
3.2.1 Microcrystalline cellulose 46
3.2.2 Powdered cellulose 47
3.2.3 Methylcellulose 48
3.2.4 Ethylcellulose 50
3.2.5 Hydroxyethyl cellulose 52
3.2.6 Hydroxypropyl cellulose 54
3.2.7 Hydroxypropyl methylcellulose 56
3.2.8 Carboxymethylcellulose sodium 59
3.2.9 Carboxymethylcellulose calcium 60
3.2.10 Cellulose acetate phthalate 61
本節(jié)中文導(dǎo)讀 63
3.3 Other natural polymers in pharmaceutics 66
3.3.1 Chitin/chitosan 66
3.3.2 Alginate and sodium/calcium alginate 68
3.3.3 Acacia 71
3.3.4 Xanthan gum 72
3.3.5 Gelatin 74
3.3.6 Albumin 76
本節(jié)中文導(dǎo)讀 78
References 80
Chapter 4. Synthetic Polymers as Pharmaceutical Excipients
合成的藥用高分子敷料 81
4.1 Polymers based on polyvinyl 81
4.1.1 Polyvinyl alcohol 81
4.1.2 Polymethacrylates 83
4.1.3 Polyvinylpyrrolidone (Povidone) 87
4.1.4 Crospovidone 89
4.1.5 Carbomer 90
本節(jié)中文導(dǎo)讀 93
4.2 Polymers based on polyether 95
4.2.1 Polyethylene glycol 95
4.2.2 Poloxamer 99
4.2.3 Polysorbates 102
本節(jié)中文導(dǎo)讀 105
References 106
Chapter 5. Novel Synthetic Biodegradable Polymers as Drug
Delivery Carrier
新型可生物降解的合成藥用高分子材料 107
5.1 Introduction 107
5.2 Polymers based on polyester 108
5.2.1 Poly(lactic acid) and poly(lactic-co-glycolic acid) copolymers 108
5.2.2 Polycaprolactone 111
5.2.3 Poly(β-hydroxybutyrate) 112
5.3 Other biodegradable polymers 113
5.3.1 Poly(orthoesters) 113
5.3.2 Poly(phosphate esters) 115
5.3.3 Polyanhydrides 116
5.3.4 Poly(amino acids) 117
5.3.5 Polyphosphazenes 119
本章中文導(dǎo)讀 121
References 124
Chapter 6. Advanced Applications of Functional Polymer in Drug Delivery
功能高分子材料在藥物輸送中的應(yīng)用進(jìn)展 125
6.1 Hydrogels for pharmaceutical application 125
6.1.1 Introduction 125
6.1.2 Preparation of hydrogels 126
6.1.3 Properties of hydrogels 127
6.1.4 Pharmaceutical applications of hydrogels 129
本節(jié)中文導(dǎo)讀 133
6.2 Polymer-based nanomedicine and self-assemblying polymers 134
6.2.1 Introduction to nanomedicine 134
6.2.2 Micellation of self-assemblying polymers 134
6.2.3 Biological significance of polymeric micelles 136
6.2.4 Drug release from polymeric micelles 137
6.2.5 Examples of polymeric micelles for drug delivery 138
本節(jié)中文導(dǎo)讀 141
6.3 Polymer-drug conjugates 142
6.3.1 Introduction 142
6.3.2 Design and development of polymer-drug conjugates 144
6.3.3 Examples for polymer-drug conjugates 146
本節(jié)中文導(dǎo)讀 152
6.4 Polymers for gene delivery 153
6.4.1 Introduction to gene delivery 153
6.4.2 Polymeric vectors 154
本節(jié)中文導(dǎo)讀 161
References 162

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